Fearful that the neurotic Florence Unger, fresh from being dumped by her husband, might attempt suicide, Olive Madison invites her to move in as her roommate. However, Olive and Florence have very different personalities. Where Olive is messy, untidy, and unconcerned about the state of her apartment, Florence is obsessively clean, tidy, and obsessed with hygiene.

Olive’s easy-going outlook on life soon clashes with Florence’s highly-strung neurotic tendencies, testing their friendship to the limit. When Olive organizes a double-date with the Costazuela brothers, their differences come to a head and sparks fly.