Hollywood star Charlize Theron will be the guest of honor at one of Dallas' hottest-ticket galas of 2026: She will receive amfAR's Award of Inspiration at the organization's black-tie ball on October 24.

For a second year, the glamorous fall fundraiser will take place at the home of Kathleen and Scott Kirby, a release says. Taking over where Dallas' TWO x TWO gala left off when it ended in 2024, the amFAR gala has quickly become one of Dallas' marquee social events, drawing philanthropists, collectors, and high-profile guests in support of amfAR's mission to end HIV/AIDS.

Theron, who won an Oscar for Monster, is currently on a worldwide press tour ahead of her starring role in one of the summer's biggest movies, The Odyssey, Christopher Nolan's highly anticipated adaptation of the Homer epic (opening July 17).

Beyond her film career, Theron serves as a United Nations Messenger of Peace and founded the Charlize Theron Africa Outreach Project (CTAOP), which supports organizations focused on youth health, HIV prevention, sexual and reproductive health, and combating gender-based violence across Southern Africa.

"Charlize Theron’s longstanding support of amfAR and HIV/AIDS care and prevention through her own foundation make her an inspiration to us all," said amfAR CEO Kyle Clifford in a statement. "We are grateful to her for her tireless work and are thrilled to be able to recognize her at our event in Dallas this year."

According to amfAR, programs supported by CTAOP have reached more than 4.8 million young people. During the COVID-19 pandemic, Theron and the foundation also launched the Together for Her campaign with CARE and the Entertainment Industry Foundation to address gender-based violence, and later partnered with the Ford Foundation to advocate for global vaccine equity.

Founded in 1985, amfAR has invested more than $950 million in research grants supporting HIV/AIDS and other diseases in which viruses and the immune system play a significant role. Over the past 26 years, supporters in North Texas have raised more than $66.5 million to advance amFAR's ongoing HIV research and global health initiatives, the organization says.

This year's gala will feature cocktails, a seated dinner, musical performances, and a live auction offering luxury goods, travel experiences, and contemporary art. Tickets and table sponsorships are now available, starting at $2,500.